Retatrutide for Men: Benefits, Dosing and Side Effect Guide

Men and GLP-1 Drugs: Response Differences

Men tend to lose slightly less weight than women on GLP-1 drugs, a pattern observed across semaglutide, tirzepatide, and expected for retatrutide based on the available data. In the SURMOUNT-1 trial for tirzepatide, men lost an average of 18% while women lost 22%. The TRIUMPH trials have not published sex-stratified results as of May 2026, but the same pattern is likely. The difference may relate to hormonal influences on metabolism, differences in body composition, or behavioral factors including dietary adherence.

Retatrutide and Testosterone

Weight loss itself can increase testosterone levels in men with obesity. Adipose tissue contains the enzyme aromatase, which converts testosterone to estrogen. Losing fat mass reduces aromatase activity, which can increase circulating testosterone. The magnitude of weight loss produced by retatrutide — 28.3% average — is large enough to produce meaningful increases in testosterone for men with obesity-related low testosterone. Some bodybuilders on Reddit report stacking retatrutide with testosterone replacement therapy, though no clinical data exists on this combination.